Ethyl 4,5-difluoro-2-methyl-1H-indole-3-carboxylate

Ethyl 4,5-difluoro-2-methyl-1H-indole-3-carboxylate - Names and Identifiers

Name	4,5-Difluoro-2-methylindole-3-carboxylic acid ethyl ester
Synonyms	Ethyl 4,5-difluoro-2-methylindole-3-carboxylate ethyl 4,5-difluoro-2-methyl-1H-indole-3-carboxylate Ethyl 4,5-difluoro-2-methyl-1H-indole-3-carboxylate 4,5-Difluoro-2-methylindole-3-carboxylic acid ethyl ester 1H-Indole-3-carboxylic acid, 4,5-difluoro-2-methyl-, ethyl ester
CAS	886362-67-0
EINECS	213-454-1
InChI	InChI=1/C12H11F2NO2/c1-3-17-12(16)9-6(2)15-8-5-4-7(13)11(14)10(8)9/h4-5,15H,3H2,1-2H3

Ethyl 4,5-difluoro-2-methyl-1H-indole-3-carboxylate - Physico-chemical Properties

Molecular Formula	C12H11F2NO2
Molar Mass	239.22
Density	1.321g/cm³
Boling Point	352.8°C at 760 mmHg
Flash Point	167.1°C
Vapor Presure	3.76E-05mmHg at 25°C
Storage Condition	2-8°C
Refractive Index	1.574

Ethyl 4,5-difluoro-2-methyl-1H-indole-3-carboxylate - Introduction

4. Acid ethyl ester is an organic compound whose chemical formula is C12H10F2NO2. It has a colorless or pale yellow solid and is soluble in organic solvents such as chloroform and ethanol.

4, acid ethyl ester is commonly used as an intermediate in drug synthesis. The compound can be used to synthesize a series of indole derivatives with biological activity, such as anti-tumor drugs and anti-inflammatory drugs. Indole compounds have attracted much attention due to their diverse biological activities.

The method for preparing 4, 2 acid ethyl ester is generally obtained by reacting-methylindole with 2-fluoroethyl acetate under acidic conditions. First, 2-methylindole is reacted with diethyltin bromide (Sn(CH2CH3)2Br2) to generate a product in which an ethyl acetate group is introduced at the C2 position, and then hydrochlorinated to generate hydrofluorination using reagents such as hydrofluoric acid (HF) and trifluoroacetic acid (CF3COOH).

Regarding the safety information of 4, acid ethyl ester, it is an organic compound and should be kept away from light and away from fire sources. Wear appropriate protective equipment to avoid contact with skin and eyes during handling and use. In case of contact with skin, rinse immediately with plenty of water. If inhaled or ingested, seek medical attention immediately. During storage and handling, the relevant safety procedures shall be observed.

Last Update：2024-04-09 21:54:55